Wednesday, April 4, 2007

Wednesday April 4, 2007
Daptomycin (Cubicin) and renal failure

As Daptomycin has now been approved for right-sided MSSA and MRSA endocarditis since our previous pearl *, and as we are seeing it more in ICUs, it would be of worth to re-visit that, Cubicin needs to be adjusted in renal failure. With CrCl less than 30, it should be given every 48 hours. It is recommended to be given on hemodialysis day following hemodialysis. Daptomycin doesn't get cleared in CVVHD and need to adjusted as renal failure dose.


Related previous pearls:

Daptomycin induced rhabdomyolysis

3 new antibiotics *

* Since this previous pearl, Cubicin is approved for right-sided MSSA and MRSA endocarditis.

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